Cell and Tissue Engineering

Cells are the fundamental components that make up tissues and organs. Our goal is to control cell functions and determine their fate through stem cell differentiation, cell reprogramming, and synthetic biology approaches, which can lead to more effective therapies. To achieve successful tissue regeneration, it is essential to understand how immune cells, stem cells, and resident cells interact in the microenvironment. Our lab conducts research on the mechanisms of tissue remodeling and employs a multidisciplinary approach that involves engineering cells, biomaterials, drug delivery systems, and biophysical therapies. The lab’s current focus is on the regeneration of cardiovascular, neuromuscular, and connective tissues.

Publication Highlights


May 2022

Immunoengineering strategies to enhance vascularization and tissue regeneration

Advanced Drug Delivery Reviews

Jana Zarubova, Mohammad M Hasani-Sadrabadi, Reza Ardehali, Song Li


Mar 2021

Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro.

Nat Biomedi Eng.

Jun Fang, Junren Sia, Jennifer Soto, Pingping Wang, LeeAnn K. Li, Yuan-Yu Hsueh, Raymond Sun, Kym Francis Faull, James G. Tidball & Song Li


Feb 2021

Asymmetric Cell Division of Fibroblasts is An Early Deterministic Step to Generate Elite Cells during Cell Reprogramming.

 Advanced Science.

Song Y, Soto J, Wang P, An Q, Zhang X, Hong S, Lee LP, Fan G, Yang L, Li S.


Jan 2021

Cellular remodeling of fibrotic conduit as vascular graft.

Biomaterials. 268:120565.

Qiu X, Lee BL, Wong SY, Ding X, Xu K, Zhao W, Wang D, Sochol R, Dong N, Li S.


Mar 2020

An engineered cell-laden adhesive hydrogel promotes craniofacial bone tissue regeneration in rats.

Sci Transl Med. 11;12(534).

Hasani-Sadrabadi MM, Sarrion P, Pouraghaei S, Chau Y, Ansari S, Li S, Aghaloo T, Moshaverinia A.


Mar 2020

Injectable Drug‐Releasing Microporous Annealed Particle Scaffolds for Treating Myocardial Infarction.

Adv Func Mater. 30(43):2004307.

Fang J, Koh J, Fang Q, Qiu H, Archang MM, Hasani-Sadrabadi MM, Miwa H, Zhong X, Sievers R, Gao D, Lee R, Di Carlo D, Li S.


Nov 2012

The effect of stromal cell-derived factor-1α/heparin coating of biodegradable vascular grafts on the recruitment of both endothelial and smooth muscle progenitor cells for accelerated regeneration.

Biomaterials. 33(32):8062-8074.

Yu J, Wang A, Tang Z, Henry J, Li-Ping Lee B, Zhu Y, Yuan F, Huang F, Li S.


Jun 2012

Differentiation of multipotent vascular stem cells contributes to vascular diseases.

Nature Commmunications. 3:875.

Tang, Z, Wang, A, Yuan, F, Yan, Z, Liu, B, Chu, JS, Helms JA, Li S.


Aug 2011

Induced pluripotent stem cells for neural tissue engineering.

Biomaterials. 32(55):5023-32.

Wang A, Tang Z, Park IH, Zhu Y, Patel S, Daley GQ, Li S.