Immune cells play important roles in tissue regeneration, infectious diseases, cancer therapy, and organ transplantation. We are interested in engineering bioactive micro/nano materials and drug delivery systems to modulate immune cell activation and functions, with the goal of developing novel therapeutics. The current projects include: (1) enhance long-term memory of immune cells to fight infectious diseases and cancer, (2) modulate immune cells for tissue regeneration and disease therapy (e.g., diabetes).



Publication Highlights


December 2021

Immunomodulatory microneedle patch for periodontal tissue regeneration

Matter 5, 1–17

Xuexiang Zhang, Mohammad Mahdi Hasani-Sadrabadi, Jana Zarubova, Erfan Dashtimighadam, Reihaneh Haghniaz, Ali Khademhosseini, Manish J. Butte, Alireza Moshaverinia, Tara Aghaloo, Song Li.


May 2021

Biomaterial-based Immunoengineering to Fight COVID-19 and Infectious Diseases.


Zarubova J, Zhang X, Hoffman T, Hasani-Sadrabadi MM, Li S.


Dec 2020

Unraveling the mechanobiology of immune cells.

Current Opinion in Biotechnology. 66:236-245.

Zhang X, Kim T, Thauland TJ, Li H, Majedi FS, Ly C, Gu Z, Butte MJ, Rowat AC, Li S.


Sep 2020

Augmenting T-cell responses to tumors by in situ nanomanufacturing.

Materials Horizons. 7:3028-3033.

Hasani-Sadrabadi MM, Majedi FS, Miller M, Thauland TJ, Bouchard LS, Li S*, Butte MJ*.