The role of immune cells is critical in a variety of medical applications, including tissue regeneration, combating infectious diseases, cancer therapy, and organ transplantation. Our research focus is on developing innovative therapies through the engineering of bioactive micro/nano materials and drug delivery systems that can effectively regulate immune cell activation and functions. Our current projects aim to: (1) improve immune cell memory to effectively combat both infectious diseases and cancer, and (2) manipulate immune cells to promote tissue regeneration and provide therapy for diseases such as diabetes.

Publication Highlights


December 2022

Systemic enhancement of antitumour immunity by peritumourally implanted immunomodulatory macroporous scaffolds

Nature Biomedical Engineering 7, 56–71

Fatemeh S. Majedi, Mohammad Mahdi Hasani-Sadrabadi, Timothy J. Thauland, Sundeep G. Keswani, Song Li, Louis-S. Bouchard & Manish J. Butte


December 2021

Immunomodulatory microneedle patch for periodontal tissue regeneration

Matter 5, 1–17

Xuexiang Zhang, Mohammad Mahdi Hasani-Sadrabadi, Jana Zarubova, Erfan Dashtimighadam, Reihaneh Haghniaz, Ali Khademhosseini, Manish J. Butte, Alireza Moshaverinia, Tara Aghaloo, Song Li.


May 2021

Biomaterial-based Immunoengineering to Fight COVID-19 and Infectious Diseases.


Zarubova J, Zhang X, Hoffman T, Hasani-Sadrabadi MM, Li S.


Dec 2020

Unraveling the mechanobiology of immune cells.

Current Opinion in Biotechnology. 66:236-245.

Zhang X, Kim T, Thauland TJ, Li H, Majedi FS, Ly C, Gu Z, Butte MJ, Rowat AC, Li S.


Sep 2020

Augmenting T-cell responses to tumors by in situ nanomanufacturing.

Materials Horizons. 7:3028-3033.

Hasani-Sadrabadi MM, Majedi FS, Miller M, Thauland TJ, Bouchard LS, Li S*, Butte MJ*.