Publications 1990-2004



The attachment, proliferation, and wound healing of endothelial and smooth muscle cells on nitinol thin film in vitro.

Conf Proc IEEE Eng Med Biol Soc.

Lam HJ, Li S, Leong IP, Menchaca L, Johnson AD.



Endothelial cell function on a poly(acrylamide-co-polyethylene acid) interpenetrating polymer network: cardiovascular applications.

Conf Proc IEEE Eng Med Biol Soc.

Patel SH, Tsang J, Harbers G, Healy KE, Li S.



Synthetic peptides cytomodulin-1 (CM-1) and cytomodulin-2 (CM-2) promote collagen synthesis and wound healing in vitro.

Conf Proc IEEE Eng Med Biol Soc.

Lam HJ, Li S, Lou N, Chu J, Bhatnagar RS.



Mechanical regulation of matrix reorganization and phenotype of smooth muscle cells and mesenchymal stem cells in 3D matrix.

Conf Proc IEEE Eng Med Biol Soc.

Liao SW, Hida K, Park JS, Li S.



Biomimetic scaffolds for tissue engineering.

Conf Proc IEEE Eng Med Biol Soc.

Bhatnagar R, Li S.


Nov 2004

Differential effects of equiaxial and uniaxial strains on mesenchymal stem cells.

Biotechnology and Bioengineering (Special Issue on Stem Cell Engineering) 14;88(3):359-368.

Park J, Chu J, Cheng C, Chen F, Chen DJ, and Li S.


Oct 2004

Proteomic profiling of bone marrow mesenchymal stem cells upon TGF-Beta stimulation.

J Biol Chem. 279(42):43725-43734.

Wang D, Park JS, Chu JS, Krakowski A, Luo K, Chen DJ, Li S.


Feb 2004

PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells.

Proc Natl Acad Sci USA.101:2311.

Zhang MZ, Mai W, Li C, Cho SY, Hao C, Moeckel G, Zhao R, Kim I, Wang J, Xiong H, Wang H, Sato Y, Wu Y, Nakanuma Y, Lilova M, Pei Y, Harris RC, Li S, Coffey RJ, Sun L, Wu D, Chen XZ, Breyer MD, Zhao ZJ, McKanna JA, Wu G.


Jul-Aug 2004

Biomimetic collagen scaffolds for human bone cell growth & differentiation.

Tissue Eng 10(7-8):1148-59.

Yang XB, Bhatnagar RS, Li S, and Oreffo ROC.


Apr 2004

Rho mediates the shear-enhancement of endothelial cell migration and traction force generation.

Biophys J.86:2558-65.

Shiu YT, Li S, Marganski WA, Usami S, Schwartz MA, Wang YL, Dembo M, Chien S.


Nov 2003

Enhanced cell attachment and osteoblastic activity by P-15 peptide-coated matrix in hydrogels.

Biochem Biophys Res Commun.311:179-86.

Nguyen H, Qian JJ, Bhatnagar RS, Li S.


Aug 2003

Regulation of vascular smooth muscle cells by micropatterning.

Biochem Biophys Res Commun.307:883-890.

Thakar RG, Ho F, Huang NF, Liepmann D, Li S.


Jul-Aug 2003

Signal Transduction in Matrix Contraction and the Migration of Vascular Smooth Muscle Cells in Three-Dimensional Matrix.

J Vasc Res.40:378-388.

Li S, Moon JJ, Miao H, Jin G, Chen BP, Yuan S, Hu Y, Usami S, Chien S.


Apr 2003

Shear stress- induced c-fos activation is mediated by Rho in a calcium-dependent manner.

Biochem Biophys Res Commun. 303:548-555.

Shiu YT, Li S, Yuan SL, Wang YX, Nguyen P, Chien S.


Jan 2003

Genomic analysis of smooth muscle cells in 3-dimensional collagen matrix.

FASEB J.17:97-9.

Li S, Lao J, Chen BP, Li YS, Zhao Y, Chu J, Chen KD, Tsou TC, Peck K, Chien S.


Nov 2002

Interplay between integrins and FLK-1 in shear stress-induced signaling.

Am J Physiol Cell Physiol.283:C1540-7.

Wang Y, Miao H, Li S, Chen KD, Li YS, Yuan S, Shyy JY, Chien S.


Nov-Dec 2002

Roles of microtubule dynamics and small GTPase rac in endothelial cell migration and lamellipodium formation under flow.

Journal of Vascular Research.39:465-476.

Hu YL, Li S, Miao H, Tsou TC, del Pozo MA, Chien S.


Dec 2002

Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression.

EMBO J.21:6791-800.

Tzima E, Del Pozo MA, Kiosses WB, Mohamed SA, Li S, Chien S, Schwartz MA.


May 2002

Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling.

J Cell Sci.115:2199-206.

Miao H, Li S, Hu YL, Yuan S, Zhao Y, Chen BP, Puzon-McLaughlin W, Tarui T, Shyy JY, Takada Y, Usami S, Chien S.


Mar 2002

The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells.

Proc Natl Acad Sci U S A.99:3546-51.

Li S, Butler P, Wang Y, Hu Y, Han DC, Usami S, Guan JL, Chien S.


Jul 2001

Effects of flow patterns on endothelial cell migration into a zone of mechanical denudation.

Biochem Biophys Res Commun.285:751-9.

Hsu PP, Li S, Li YS, Usami S, Ratcliffe A, Wang X, Chien S.


Oct 2001

DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress.

Physiol Genomics.7:55-63.

Chen BP, Li YS, Zhao Y, Chen KD, Li S, Lao J, Yuan S, Shyy JY, Chien S.



Effects of morphological patterning on endothelial cell migration.


Li S, Bhatia S, Hu YL, Shiu YT, Li YS, Usami S, Chien S.



Biomolecular Engineering of Osseointegration.

Osseointegration: From Molecule to Man.

Chien S and Li S.



Protein phosphorylation in shear stress activated endothelial cells.

Mechanical Forces and the Endothelium.

Shyy JY, Li YS, Li S, Jalali S, Kim M, and Chien S.


Nov 1999

Heat shock-induced necrosis and apoptosis in osteoblasts.

J Orthop Res.17:891-9.

Li S, Chien S, Branemark PI.


Nov-Dec 1999

Measurement of orientation and distribution of cellular alignment and cytoskeletal organization.

Ann Biomed Eng.27:712-20.

Karlon WJ, Hsu PP, Li S, Chien S, McCulloch AD, Omens JH.


Oct 1999

Sustained JNK activation induces endothelial apoptosis: studies with colchicine and shear stress.

American Journal of Physiology-Heart and Circulatory Physiology.277:H1593-H1599.

Hu YL, Li S, Shyy JYJ, Chien S.


Jun 1999

Mechanotransduction in response to shear stress – Roles of receptor tyrosine kinases, integrins, and Shc.

Journal of Biological Chemistry.274:18393-18400.

Chen KD, Li YS, Kim M, Li S, Yuan S, Chien S, Shyy JYJ.


Apr 1999

Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress.

Journal of Clinical Investigation.103:1141-50.

Li S, Chen BP, Azuma N, Hu YL, Wu SZ, Sumpio BE, Shyy JY, Chien S.


Feb 1998

Shear stress activates p60src-Ras-MAPK signaling pathways in vascular endothelial cells.

Arterioscler Thromb Vasc Biol.18:227-34.

Jalali S, Li YS, Sotoudeh M, Yuan S, Li S, Chien S, Shyy JY.



Effects of mechanical forces on signal transduction and gene expression in endothelial cells.


Chien S, Li S, Shyy JYJ.



Fluid shear stress activation of focal adhesion kinase – Linking to mitogen-activated protein kinases.

Journal of Biological Chemistry.272:30455-30462.

Li S, Kim M, Hu YL, Jalali S, Schlaepfer DD, Hunter T, Chien S, Shyy JYJ.


Nov 1996

The Ras-JNK pathway is involved in shear-induced gene expression

Am J Physiol:C994-1000.

Y S Li 1, J Y Shyy, S Li, J Lee, B Su, M Karin, S Chien.


Sep 1996

Fluid shear stress induces the phosphorylation of small heat shock proteins in vascular endothelial cells.

Am J Physiol. 1996 Sep;271(3 Pt 1):C994-1000. doi: 10.1152/ajpcell.1996.271.3.C994.

Li S, Piotrowicz RS, Levin EG, Shyy YJ, Chien S.



Three-dimensional analysis of the concentration in an electrophoresis chamber with continuous flow.

Acta Mechanica Sinica.25:29-39.

Li S, Wen GB, Yan ZY, Tao ZL.



Effect of endothelial cell shape on arterial macromolecular transport.

Acta Scientiarum Naturalium, Universitantis Pekanis.26:58-70.

Wen GB, Li S.